Structural Insight into Peroxisome Proliferator-Activated Receptor γ Binding of Two Ureidofibrate-Like Enantiomers by Molecular Dynamics, Cofactor Interaction Analysis, and Site-Directed Mutagenesis-Reference-Cited by-同舟云学术

Structural Insight into Peroxisome Proliferator-Activated Receptor γ Binding of Two Ureidofibrate-Like Enantiomers by Molecular Dynamics, Cofactor Interaction Analysis, and Site-Directed Mutagenesis

Published:2010-05-12 Issue:11 Volume:53 Page:4354-4366
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pochetti Giorgio¹,Mitro Nico²³,Lavecchia Antonio⁴,Gilardi Federica²,Besker Neva⁵,Scotti Elena²,Aschi Massimiliano⁶,Re Nazzareno⁵,Fracchiolla Giuseppe⁷,Laghezza Antonio⁷,Tortorella Paolo⁷,Montanari Roberta¹,Novellino Ettore⁴,Mazza Fernando¹⁸,Crestani Maurizio²,Loiodice Fulvio⁷

Affiliation:

1. Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Montelibretti, 00015 Monterotondo Stazione, Roma, Italia

2. Laboratorio “Giovanni Galli” di Biochimica e Biologia Molecolare dei Lipidi e Spettrometria di Massa

3. Laboratorio “Giovanni Armenise-Harvard Foundation”

4. Dipartimento di Chimica Farmaceutica e Tossicologica, Università degli Studi di Napoli “Federico II”, 80131 Napoli, Italia

5. Dipartimento di Scienze del Farmaco, Università “G. D’Annunzio”, 06100 Chieti, Italia

6. Dipartimento di Chimica, Ingegneria Chimica e Materiali, Università di L’Aquila, 67010 L’Aquila, Italia

7. Dipartimento Farmaco-Chimico, Università degli Studi di Bari “Aldo Moro”, 70126 Bari, Italia

8. Dipartimento di Scienze della Salute, Università di L’Aquila, 67010 L’Aquila, Italia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9013899

Reference52 articles.

1. PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth

2. A Unified Nomenclature System for the Nuclear Receptor Superfamily

3. PPARs and the complex journey to obesity

4. PPAR and human metabolic disease

5. 15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

Cited by 49 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties;European Journal of Medicinal Chemistry;2024-09

2. Electrochemical Desulfurizative Amination of Heteroaromatic Thiols by Iodine Catalysis;ChemCatChem;2024-02-16

3. Diverse pharmacological potential of pyridazine analogs against various diseases;Medicinal Chemistry;2023-09-13

4. Cobalt-Catalyzed Hypervalent Iodine(III) Promoted Cascade Annulation Reaction of Anilines with Formamides for 2-Aminobenzoxazoles Synthesis;The Journal of Organic Chemistry;2023-05-17

5. Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition;Biomolecules;2023-04-19