Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin-Reference-Cited by-同舟云学术

Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin

Published:2010-08-20 Issue:9 Volume:1 Page:472-477
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Morgan Bradley P.¹,Muci Alexander¹,Lu Pu-Ping¹,Qian Xiangping¹,Tochimoto Todd¹,Smith Whitney W.¹,Garard Marc¹,Kraynack Erica¹,Collibee Scott¹,Suehiro Ion¹,Tomasi Adam¹,Valdez S. Corey¹,Wang Wenyue¹,Jiang Hong¹,Hartman James¹,Rodriguez Hector M.¹,Kawas Raja¹,Sylvester Sheila¹,Elias Kathleen A.¹,Godinez Guillermo¹,Lee Kenneth¹,Anderson Robert¹,Sueoka Sandra¹,Xu Donghong¹,Wang Zhengping¹,Djordjevic Nebojsa¹,Malik Fady I.¹,Morgans David J.¹

Affiliation:

1. Cytokinetics, Inc., 280 East Grand Avenue, South San Francisco, California 94080

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml100138q

Reference26 articles.

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2. Effect of Oral Milrinone on Mortality in Severe Chronic Heart Failure

3. The Management of Hypertrophic Cardiomyopathy

4. A novel approach to improve cardiac performance: cardiac myosin activators

5. Finer, J. T.; Malik, F.; Sakowicz, R.; Shumate, C.; Wood, K.Compositions and assays utilizing ADP or phosphate for detecting protein modulators. U.S. Patent 6410254 B1, June 25, 2002; 13 pp.

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