Influence of Molecular Flexibility and Polar Surface Area Metrics on Oral Bioavailability in the Rat-Reference-Cited by-同舟云学术

Influence of Molecular Flexibility and Polar Surface Area Metrics on Oral Bioavailability in the Rat

Published:2004-10-23 Issue:24 Volume:47 Page:6104-6107
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lu Jing J.¹,Crimin Kimberly¹,Goodwin Jay T.¹,Crivori Patrizia¹,Orrenius Christian¹,Xing Li¹,Tandler Peter J.¹,Vidmar Thomas J.¹,Amore Benny M.¹,Wilson Alan G. E.¹,Stouten Pieter F. W.¹,Burton Philip S.¹

Affiliation:

1. Computational Chemistry and Nonclinical Statistics and CNS Drug Metabolism, Pfizer Global R&D, Groton Laboratories, Eastern Point Road, 8200-36, Groton, Connecticut 06340, ADMETRx, Inc., 4717 Campus Drive, Suite 600, Kalamazoo, Michigan 49008, Attrition Reducing Technologies and Computational Sciences, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy, Computational Chemistry, Pfizer Global Research & Development, 700 Chesterfield Parkway North, St. Louis, Missouri 63017, 128 S....

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0306529

Reference12 articles.

1. Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

2. Selection criteria for drug-like compounds

3. Application of hydrogen bonding calculations in property based drug design

4. Nonleadlikeness and leadlikeness in biochemical screening

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