Post-Column Denaturation-Assisted Native Size-Exclusion Chromatography–Mass Spectrometry for Rapid and In-Depth Characterization of High Molecular Weight Variants in Therapeutic Monoclonal Antibodies-Reference-Cited by-同舟云学术

Post-Column Denaturation-Assisted Native Size-Exclusion Chromatography–Mass Spectrometry for Rapid and In-Depth Characterization of High Molecular Weight Variants in Therapeutic Monoclonal Antibodies

Published:2021-11-17 Issue:12 Volume:32 Page:2885-2894
ISSN:1044-0305
Container-title:Journal of the American Society for Mass Spectrometry
language:en
Short-container-title:J. Am. Soc. Mass Spectrom.

Author:

Yan Yuetian¹,Xing Tao¹,Liu Anita P.¹,Zhang Zhengqi¹,Wang Shunhai¹^ORCID,Li Ning¹

Affiliation:

1. Analytical Chemistry Group, Regeneron Pharmaceuticals Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707, United States

Publisher

American Chemical Society (ACS)

Subject

Spectroscopy,Structural Biology

Link

https://pubs.acs.org/doi/pdf/10.1021/jasms.1c00289

Reference33 articles.

1. Therapeutic protein aggregation: mechanisms, design, and control

2. Non-enzymatic hinge region fragmentation of antibodies in solution

3. Structural effect of a recombinant monoclonal antibody on hinge region peptide bond hydrolysis

4. Characterization of product-related low molecular weight impurities in therapeutic monoclonal antibodies using hydrophilic interaction chromatography coupled with mass spectrometry

5. Fragmentation of monoclonal antibodies

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