Probing the Structure−Function Relationship of Polyene Macrolides: Engineered Biosynthesis of Soluble Nystatin Analogues-Reference-Cited by-同舟云学术

Probing the Structure−Function Relationship of Polyene Macrolides: Engineered Biosynthesis of Soluble Nystatin Analogues

Published:2006-03-23 Issue:8 Volume:49 Page:2431-2439
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Borgos Sven E. F.¹,Tsan Pascale¹,Sletta Håvard¹,Ellingsen Trond E.¹,Lancelin Jean-Marc¹,Zotchev Sergey B.¹

Affiliation:

1. Department of Biotechnology, Norwegian University of Science and Technology, N-7491 Trondheim, Norway, RMN Biomoléculaire, Unité mixte de Recherche, Université Claude BernardLyon 1, CNRS Sciences Analytiques, ESCPE, Lyon, F-69622 Villeurbanne, France, and Department of Biotechnology, SINTEF Materials and Chemistry, N-7034 Trondheim, Norway

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050895w

Reference46 articles.

1. Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species

2. Modular organization of genes required for complex polyketide biosynthesis

3. Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway

4. Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin inSaccharopolyspora erythraea

5. Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of genes flanking the polyketide synthase

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