Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands-Reference-Cited by-同舟云学术

Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands

Published:2010-09-09 Issue:19 Volume:53 Page:7192-7201
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

de Kloe Gerdien E.¹,Retra Kim²,Geitmann Matthis³,Källblad Per³,Nahar Tariq⁴,van Elk René⁴,Smit August B.⁴,van Muijlwijk-Koezen Jacqueline E.¹,Leurs Rob¹,Irth Hubertus²,Danielson U. Helena³⁵,de Esch Iwan J. P.¹

Affiliation:

1. Leiden/Amsterdam Center for Drug Research (LACDR), Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

2. Leiden/Amsterdam Center for Drug Research (LACDR), Division of BioMolecular Analysis, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

3. Beactica AB, Box 567, SE-751 22 Uppsala, Sweden

4. Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands

5. Department of Biochemistry and Organic Chemistry, Uppsala University, BMC, Box 576, SE-751 23, Uppsala, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100834y

Reference44 articles.

1. Transforming fragments into candidates: small becomes big in medicinal chemistry

2. Fragment Library Screening and Lead Characterization Using SPR Biosensors

3. Fragment Screening by Surface Plasmon Resonance

4. SAR by MS: A Ligand Based Technique for Drug Lead Discovery Against Structured RNA Targets

5. Discovering novel ligands for macromolecules using X-ray crystallographic screening

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