Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors-Reference-Cited by-同舟云学术

Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors

Published:2006-01-10 Issue:3 Volume:49 Page:955-970
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jung Frédéric H.¹,Pasquet Georges¹,Lambert-van der Brempt Christine¹,Lohmann Jean-Jacques M.¹,Warin Nicolas¹,Renaud Fabrice¹,Germain Hervé¹,De Savi Chris¹,Roberts Nicola¹,Johnson Trevor¹,Dousson Cyril¹,Hill George B.¹,Mortlock Andrew A.¹,Heron Nicola¹,Wilkinson Robert W.¹,Wedge Stephen R.¹,Heaton Simon P.¹,Odedra Rajesh¹,Keen Nicholas J.¹,Green Stephen¹,Brown Elaine¹,Thompson Katherine¹,Brightwell Stephen¹

Affiliation:

1. AstraZeneca, Centre de Recherches, Parc Industriel Pompelle, BP1050, Chemin de Vrilly, 51689 Reims Cedex2, France, and AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050786h

Reference55 articles.

1. The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis

2. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

3. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

4. The cellular geography of Aurora kinases

5. The Kinase Activity of Aurora B Is Required for Kinetochore-Microtubule Interactions during Mitosis

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