Manipulation of the Nanoscale Presentation of Integrin Ligand Produces Cancer Cells with Enhanced Stemness and Robust Tumorigenicity

Author:

Wong Siu Hong Dexter12ORCID,Xu Xiao3,Chen Xi14,Xin Ying14,Xu Limei3,Lai Chun Him Nathanael2,Oh Jiwon2,Wong Wai Ki Ricky2,Wang Xuemei2,Han Shisong256ORCID,You Wenxing27,Shuai Xintao56ORCID,Wong Nathalie27,Tan Youhua14ORCID,Duan Li3,Bian Liming289ORCID

Affiliation:

1. Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, 999077, China

2. Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, 999077, China

3. Department of Orthopedics, Shenzhen Intelligent Orthopaedics and Biomedical Innovation Platform, Guangdong Artificial Intelligence Biomedical Innovation Platform, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, China

4. Shenzhen Research Institute, The Hong Kong Polytechnic University, Shenzhen 518000, China

5. PCFM Lab of Ministry of Education, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, China

6. Laboratory of Interventional Radiology, Department of Minimally Invasive Interventional Radiology, and Department of Radiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China

7. Department of Surgery at Sir Y. K. Pao Centre for Cancer, The Chinese University of Hong Kong, Hong Kong, 999077, China

8. Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, 518172, China

9. China Orthopedic Regenerative Medicine Group (CORMed) Hangzhou, Zhejiang, 310058, China

Funder

Food and Health Bureau

Health and Medical Research Fund

Research Grants Council, University Grants Committee

Science, Technology and Innovation Commission of Shenzhen Municipality

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Chinese University of Hong Kong

Chow Yuk Ho Technology Centre for Innovative Medicine

Guangdong Province

Shenzhen Municipality

Hong Kong Special Administrative Region

Publisher

American Chemical Society (ACS)

Subject

Mechanical Engineering,Condensed Matter Physics,General Materials Science,General Chemistry,Bioengineering

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