Lipid Nanoparticle RBD-hFc mRNA Vaccine Protects hACE2 Transgenic Mice against a Lethal SARS-CoV-2 Infection-Reference-Cited by-同舟云学术

Lipid Nanoparticle RBD-hFc mRNA Vaccine Protects hACE2 Transgenic Mice against a Lethal SARS-CoV-2 Infection

Published:2021-05-25 Issue:11 Volume:21 Page:4774-4779
ISSN:1530-6984
Container-title:Nano Letters
language:en
Short-container-title:Nano Lett.

Author:

Elia Uri¹²³⁴⁵^ORCID,Rotem Shahar⁵,Bar-Haim Erez⁵,Ramishetti Srinivas¹²³⁴,Naidu Gonna Somu¹²³⁴,Gur David⁵,Aftalion Moshe⁵,Israeli Ma’ayan⁵,Bercovich-Kinori Adi⁵,Alcalay Ron⁵,Makdasi Efi⁶,Chitlaru Theodor⁵,Rosenfeld Ronit⁵,Israely Tomer⁶,Melamed Sharon⁶,Abutbul Ionita Inbal⁷,Danino Dganit⁷,Peer Dan¹²³⁴^ORCID,Cohen Ofer⁵

Affiliation:

1. Laboratory of Precision NanoMedicine, Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel

2. Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 69978, Israel

3. Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel

4. Cancer Biology Research Center, Tel Aviv University, Tel Aviv 69978, Israel

5. Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona 76100, Israel

6. Department of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona 76100, Israel

7. CryoEM Laboratory of Soft Matter, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel

Funder

Lewis Trust grant

Publisher

American Chemical Society (ACS)

Subject

Mechanical Engineering,Condensed Matter Physics,General Materials Science,General Chemistry,Bioengineering

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.nanolett.1c01284

Reference24 articles.

1. World Health Organization. Weekly epidemiological update on COVID-19. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20210323_weekly_epi_update_32.pdf (accessed 2021-03-23).

2. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

3. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

4. Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems

5. Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

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