Design, Synthesis, and Biological Evaluation of Novel Tri- and Tetrasubstituted Imidazoles as Highly Potent and Specific ATP-Mimetic Inhibitors of p38 MAP Kinase: Focus on Optimized Interactions with the Enzyme’s Surface-Exposed Front Region-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of Novel Tri- and Tetrasubstituted Imidazoles as Highly Potent and Specific ATP-Mimetic Inhibitors of p38 MAP Kinase: Focus on Optimized Interactions with the Enzyme’s Surface-Exposed Front Region

Published:2008-06-26 Issue:14 Volume:51 Page:4122-4149
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Laufer Stefan A.¹,Hauser Dominik R. J.¹,Domeyer David M.¹,Kinkel Katrin¹,Liedtke Andy J.¹

Affiliation:

1. Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard-Karls-University Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm701529q

Reference76 articles.

1. Protein Kinase Inhibitors: Insights into Drug Design from Structure

2. MAP Kinases

3. The Biology of p38 Kinase: A Central Role in Inflammation

4. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

5. 1 p38 MAP Kinase: Molecular Target for the Inhibition of Pro-inflammatory Cytokines

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