Chemo-Enzymatic Synthesis of (2S,4R)-2-Amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic Acid: A Novel Selective Inhibitor of Human Excitatory Amino Acid Transporter Subtype 2-Reference-Cited by-同舟云学术

Chemo-Enzymatic Synthesis of (2S,4R)-2-Amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic Acid: A Novel Selective Inhibitor of Human Excitatory Amino Acid Transporter Subtype 2

Published:2008-06-25 Issue:14 Volume:51 Page:4085-4092
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sagot Emanuelle¹,Jensen Anders A.¹,Pickering Darryl S.¹,Pu Xiaosui¹,Umberti Michelle¹,Stensbøl Tine B.¹,Nielsen Birgitte¹,Assaf Zeinab¹,Aboab Bétina¹,Bolte Jean¹,Gefflaut Thierry¹,Bunch Lennart¹

Affiliation:

1. Department of Medicinal Chemistry, The Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark, Département de Chimie, Université Blaise Pascal, 63177 Aubière Cedex, France, Department of Pharmacology and Pharmacotherapy, The Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark, Biological Research, H. Lundbeck A/S, 215 College Road, Paramus, New Jersey 07652, Department of Neurobiology, H....

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800091e

Reference23 articles.

1. Neuronal High-Affinity Sodium-Dependent Glutamate Transporters (EAATs): Targets for the Development of Novel Therapeutics Against Neurodegenerative Diseases

2. EXCITATORY AMINO ACID TRANSPORTERS: A Family in Flux

3. Ligands for Glutamate Receptors: Design and Therapeutic Prospects

4. Glutamate as a Neurotransmitter in the Brain: Review of Physiology and Pathology

5. Rational Design and Enantioselective Synthesis of (1R,4S,5R,6S)-3-Azabicyclo[3.3.0]octane-4,6-dicarboxylic Acid A Novel Inhibitor at Human Glutamate Transporter Subtypes 1, 2, and 3

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