Empirical Regioselectivity Models for Human Cytochromes P450 3A4, 2D6, and 2C9-Reference-Cited by-同舟云学术

Empirical Regioselectivity Models for Human Cytochromes P450 3A4, 2D6, and 2C9

Published:2007-06-19 Issue:14 Volume:50 Page:3173-3184
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sheridan Robert P.¹,Korzekwa Kenneth R.¹,Torres Rhonda A.¹,Walker Matthew J.¹

Affiliation:

1. Molecular Systems Department, RY50S-100, Merck Research Laboratories, Rahway, New Jersey 07065, Drug Metabolism Department, WP75A-203, Merck Research Laboratories, West Point, Pennsylvania 19486, and Department of Chemistry, Washington State University, Pullman, Washington 99164-4630

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0613471

Reference23 articles.

1. In vivo metabolite detection and identification in drug discovery via LC-MS/MS with data-dependent scanning and postacquisition data mining

2. Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions

3. THE HUMAN CYP3A SUBFAMILY: PRACTICAL CONSIDERATIONS*

4. Computational Models for Cytochrome P450: A Predictive Electronic Model for Aromatic Oxidation and Hydrogen Atom Abstraction

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