New Arylthioindoles and Related Bioisosteres at the Sulfur Bridging Group. 4. Synthesis, Tubulin Polymerization, Cell Growth Inhibition, and Molecular Modeling Studies-Reference-Cited by-同舟云学术

New Arylthioindoles and Related Bioisosteres at the Sulfur Bridging Group. 4. Synthesis, Tubulin Polymerization, Cell Growth Inhibition, and Molecular Modeling Studies

Published:2009-07-14 Issue:23 Volume:52 Page:7512-7527
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

La Regina Giuseppe¹,Sarkar Taradas²,Bai Ruoli²,Edler Michael C.²,Saletti Roberto³,Coluccia Antonio³,Piscitelli Francesco¹,Minelli Lara¹,Gatti Valerio¹,Mazzoccoli Carmela¹,Palermo Vanessa⁴,Mazzoni Cristina⁴,Falcone Claudio⁴,Scovassi Anna Ivana⁵,Giansanti Vincenzo⁵,Campiglia Pietro⁶,Porta Amalia⁷,Maresca Bruno⁷,Hamel Ernest²,Brancale Andrea³,Novellino Ettore⁸,Silvestri Romano¹

Affiliation:

1. Istituto Pasteur—Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzale Aldo Moro 5, I-00185 Roma, Italy

2. Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702

3. Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, U.K.

4. Dipartimento di Biologia Cellulare e dello Sviluppo, Sapienza Università di Roma, Piazzale Aldo Moro 5, I-00185 Roma, Italy

5. Istituto di Genetica Molecolare—Consiglio Nazionale delle Ricerche, Via Abbiategrasso 207, I-27100 Pavia, Italy

6. Università di Salerno, Dipartimento di Scienze Farmaceutiche, Sezione Chimico-Tecnologica, Via Ponte don Melillo, I-84084 Fisciano, Salerno, Italy

7. Università di Salerno, Dipartimento di Scienze Farmaceutiche, Sezione Biomedica, Via Ponte don Melillo, I-84084 Fisciano, Salerno, Italy

8. Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli Federico II, Via Domenico Montesano 49, I-80131, Napoli, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900016t

Reference32 articles.

1. Newer Cytotoxic Agents: Attacking Cancer Broadly

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5. The Binding Mode of Epothilone A on α,ß-Tubulin by Electron Crystallography

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