Discovery and Synthesis of (S)-3-[2-(3,4-Dimethoxyphenyl)ethoxy]-2- (4,6-dimethylpyrimidin-2-yloxy)-3,3-diphenylpropionic Acid (LU 302872), a Novel Orally Active Mixed ETA/ETB Receptor Antagonist-Reference-Cited by-同舟云学术

Discovery and Synthesis of (S)-3-[2-(3,4-Dimethoxyphenyl)ethoxy]-2- (4,6-dimethylpyrimidin-2-yloxy)-3,3-diphenylpropionic Acid (LU 302872), a Novel Orally Active Mixed ETA/ETB Receptor Antagonist

Published:1999-07-24 Issue:16 Volume:42 Page:3026-3032
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Amberg Willi¹,Hergenröder Stefan¹,Hillen Heinz¹,Jansen Rolf¹,Kettschau Georg¹,Kling Andreas¹,Klinge Dagmar¹,Raschack Manfred¹,Riechers Hartmut¹,Unger Liliane¹

Affiliation:

1. Hauptlaboratorium, BASF AG, 67056 Ludwigshafen, Germany, and Knoll AG, 67008 Ludwigshafen, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9910425

Reference22 articles.

1. A novel potent vasoconstrictor peptide produced by vascular endothelial cells

2. Origin and Pathophysiological Role of Increased Plasma Endothelin-1 in Patients with Acute Myocardial Infarction

3. Endothelin Inhibition as a Biologic Target for Treating Hypertension

4. Prognostic value of plasma endothelin-1 in patients with chronic heart failure

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