Discovery of a Novel, Potent, and Orally Active Nonpeptide Antagonist of the Human Luteinizing Hormone-Releasing Hormone (LHRH) Receptor-Reference-Cited by-同舟云学术

Discovery of a Novel, Potent, and Orally Active Nonpeptide Antagonist of the Human Luteinizing Hormone-Releasing Hormone (LHRH) Receptor

Published:1998-10-01 Issue:22 Volume:41 Page:4190-4195
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cho Nobuo¹,Harada Masataka¹,Imaeda Toshihiro¹,Imada Takashi¹,Matsumoto Hirokazu¹,Hayase Yoji¹,Sasaki Satoshi¹,Furuya Shuichi¹,Suzuki Nobuhiro¹,Okubo Shoichi¹,Ogi Kazuhiro¹,Endo Satoshi¹,Onda Haruo¹,Fujino Masahiko¹

Affiliation:

1. Discovery Research Division, Takeda Chemical Industries, Ltd., 10 Wadai Tsukuba, Ibaraki 300-4293, Japan, and Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., 17-85 Jusohonmachi 2-chome Yodogawa-ku, Osaka 532-8686, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9803673

Reference26 articles.

1. Gonadotropin-Releasing Hormone: One Polypeptide Regulates Secretion of Luteinizing and Follicle-Stimulating Hormones

2. Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence

3. Purification, amino acid composition and N-terminus of the hypothalamic luteinizing hormone releasing factor (LRF) of ovine origin

4. Structure of the porcine LH- and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses

5. GnRH Agonists and Antagonists

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