Structure−Activity Relationships of Cysteine-Lacking Pentapeptide Derivatives That Inhibit ras Farnesyltransferase-Reference-Cited by-同舟云学术

Structure−Activity Relationships of Cysteine-Lacking Pentapeptide Derivatives That Inhibit ras Farnesyltransferase

Published:1997-01-01 Issue:2 Volume:40 Page:192-200
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Leonard Daniele M.¹,Shuler Kevon R.¹,Poulter Cynthia J.¹,Eaton Scott R.¹,Sawyer Tomi K.¹,Hodges John C.¹,Su Ti-Zhi¹,Scholten Jeffrey D.¹,Gowan Richard C.¹,Sebolt-Leopold Judith S.¹,Doherty Annette M.¹

Affiliation:

1. Departments of Chemistry, Biotechnology, and Biochemistry, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, Michigan 48105

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960602m

Reference55 articles.

1. Identification and preliminary characterization of protein-cysteine farnesyltransferase.

2. Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.

3. Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

4. Enzymatic modification of proteins with a geranylgeranyl isoprenoid.

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