Liquid–Liquid Phase Separation of the Intrinsically Disordered Domain of the Fused in Sarcoma Protein Results in Substantial Slowing of Hydration Dynamics-Reference-Cited by-同舟云学术

Liquid–Liquid Phase Separation of the Intrinsically Disordered Domain of the Fused in Sarcoma Protein Results in Substantial Slowing of Hydration Dynamics

Published:2023-12-06 Issue:49 Volume:14 Page:11224-11234
ISSN:1948-7185
Container-title:The Journal of Physical Chemistry Letters
language:en
Short-container-title:J. Phys. Chem. Lett.

Author:

Krevert Carola S.¹,Chavez Daniel²,Chatterjee Sayantan¹³,Stelzl Lukas S.⁴⁵⁶^ORCID,Pütz Sabine¹,Roeters Steven J.⁷⁸^ORCID,Rudzinski Joseph F.²⁹^ORCID,Fawzi Nicolas L.¹⁰^ORCID,Girard Martin²^ORCID,Parekh Sapun H.¹³^ORCID,Hunger Johannes¹^ORCID

Affiliation:

1. Department of Molecular Spectroscopy, Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany

2. Department of Polymer Theory, Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany

3. Department of Biomedical Engineering, The University of Texas at Austin, 107 West Dean Keeton Street, Stop C0800, Austin, Texas 78712, United States

4. KOMET 1, Institute of Physics, Johannes Gutenberg University, Staudingerweg 7, 55099 Mainz, Germany

5. Faculty of Biology, Johannes Gutenberg University Mainz, Gresemundweg 2, 55128 Mainz, Germany

6. Institute of Molecular Biology (IMB), Ackermannweg 2, 55128 Mainz, Germany

7. Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark

8. Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands

9. IRIS Adlershof, Humboldt-Universität zu Berlin, Zum Großen Windkanal 2, 12489 Berlin, Germany

10. Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, 70 Ship Street, Providence, Rhode Island 02912, United States

Funder

Welch Foundation

NIH Clinical Center

Deutsche Forschungsgemeinschaft

Human Frontier Science Program

H2020 European Research Council

National Science Foundation

ReALity

M3ODEL

Publisher

American Chemical Society (ACS)

Subject

General Materials Science,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jpclett.3c02790

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4. A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

5. The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics