α,β-Unsaturated Carbonyl System of Chalcone-Based Derivatives Is Responsible for Broad Inhibition of Proteasomal Activity and Preferential Killing of Human Papilloma Virus (HPV) Positive Cervical Cancer Cells

Author:

Bazzaro Martina1,Anchoori Ravi K.23,Mudiam Mohana Krishna R.3,Issaenko Olga1,Kumar Srinivas3,Karanam Balasubramanyam2,Lin Zhenhua2,Isaksson Vogel Rachel4,Gavioli Riccardo5,Destro Federica5,Ferretti Valeria6,Roden Richard B. S.237,Khan Saeed R.3

Affiliation:

1. Masonic Cancer Center and Department of Obstetrics, Gynecology and Women’s Heath, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, United States

2. Department of Pathology

3. Department of Oncology

4. Masonic Cancer Center Biostatistics and Bioinformatics Core, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, United States

5. Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy

6. Department of Chemistry and Center for Structural Diffractometry, University of Ferrara, I-44100, Ferrara, Italy

7. Department of Gynecology and Obstetrics

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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