A Direct Catalytic Asymmetric Mannich-type Reaction to syn-Amino Alcohols

Author:

Trost Barry M.1,Terrell Lamont R.1

Affiliation:

1. Department of Chemistry, Stanford University, Stanford, California 94305-5080

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Reference17 articles.

1. Reviews:  (a) Denmark, S. E.; Nicaise, O. J.C. InComprehensive AsymmetricCatalysis; Jacobsen, E. N., Pfaltz, A., Yamamoto, H., Eds.; Springer:  Heidelberg, 1999; pp 923−961. (b) Kleinmann, E. F. InComprehensiveOrganic Synthesis; Trost, B. M., Ed.; Pergamon Press:  New York, 1991; Vol. 2, Chapter 4.1. (c) Arend, M.; Westermann, B.; Risch, N.Angew.Chem., Int. Ed.1998,37, 1044−1070.

2. Synthesis of diastereo- and enantiomerically pure α-amino-γ-oxo acid esters by reaction of acyliminoacetates with enamines derived from 6-membered ketones

3. A Ternary Complex Reagent for an Asymmetric Reaction of Lithium Ester Enolates with Imines

4. Catalytic Enantioselective Mannich-Type Reactions Using a Novel Chiral Zirconium Catalyst

5. Catalytic Asymmetric Synthesis of Both Syn- and Anti-β-Amino Alcohols

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