Characterization of Cytochrome P450-Mediated Bioactivation of a Compound Containing the Chemical Scaffold, 4,5-Dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a Chemically Reactive p-Chlorophenyl Isocyanate Intermediate in Human Liver Microsomes-Reference-Cited by-同舟云学术

Characterization of Cytochrome P450-Mediated Bioactivation of a Compound Containing the Chemical Scaffold, 4,5-Dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a Chemically Reactive p-Chlorophenyl Isocyanate Intermediate in Human Liver Microsomes

Published:2009-08-21 Issue:9 Volume:22 Page:1603-1612
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Chen Hao¹,Zientek Michael¹,Jalaie Mehran¹,Zhang Yanhua¹,Bigge Christopher¹,Mutlib Abdul¹

Affiliation:

1. Departments of Pharmacokinetics, Dynamics and Metabolism, and Chemistry, Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, Michigan 48105

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx900167y

Reference45 articles.

1. Timing of New Black Box Warnings and Withdrawals for Prescription Medications

2. Drug-Induced Hepatotoxicity

3. Can the pharmaceutical industry reduce attrition rates?

4. The Role of Metabolic Activation in Drug Toxicity

5. Mechanisms of Acetaminophen Toxicity: Immunochemical Detection of Drug-Protein Adducts

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