Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6-Reference-Cited by-同舟云学术

Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6

Published:2021-02-04 Issue:3 Volume:34 Page:804-816
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

McGuire Jack R.¹,Bester Stephanie M.¹,Guelta Mark A.²,Cheung Jonah³^ORCID,Langley Caroline¹,Winemiller Mark D.²^ORCID,Bae Sue Y.²,Funk Vanessa²,Myslinski James M.²,Pegan Scott D.¹⁴^ORCID,Height Jude J.²

Affiliation:

1. Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, United States

2. United States Army Futures Command, Combat Capabilities Development Command, Chemical Biological Center, Chemcial Sciences Division, Agent Chemistry Branch, Aberdeen Proving Ground, Aberdeen, Maryland 21010-5424, United States

3. New York Structural Biology Center, New York, New York 10027, United States

4. United States Army Medical Research Institute of Chemical Defense, 2900 Ricketts Point Road, Aberdeen Proving Ground, Aberdeen, Maryland 21010-5400, United States

Funder

U.S. Department of Energy

U.S. Department of Defense

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.0c00406

Reference37 articles.

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3. Paddock, R., Sang-Hun, C., and Wade, N. (2017) In Kim Jong-nam’s Death, North Korea Lets Loose a Weapon of Mass Destruction. In New York Times, February 24, 2017, The New York Times Company.

4. Schwirtz, M., and Eddy, M. (2020) Aleksei Navalny Was Poisoned With Novichok, Germany Says. In New York Times, September 15, 2020, The New York Times Company.

5. (2018) Amesbury poisoning: Experts confirm substance was Novichok. In British Broadcasting Company, internet, September 4, 2018, BBC Global News Ltd.

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3. Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents;European Journal of Medicinal Chemistry;2022-08

4. Aminoalkoxy‐substituted coumarins: Synthesis and evaluation for reactivation of inhibited human acetylcholinesterase;Archiv der Pharmazie;2022-07-25

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