Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals-Reference-Cited by-同舟云学术

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Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals

Published:2017-05-04 Issue:5 Volume:30 Page:1219-1229
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Aleo Michael D.¹^ORCID,Shah Falgun²,He Kan³,Bonin Paul D.⁴,Rodrigues A. David⁵

Affiliation:

1. Drug Safety Research and Development, Pfizer Inc., Groton, Connecticut 06340, United States

2. Computational Sciences, Pfizer Inc., Cambridge, Massachusetts 02139, United States

3. Biotranex LLC, Monmouth Junction, New Jersey 08852, United States

4. Medicinal Sciences, Discovery Sciences, Pfizer Inc., Groton, Connecticut 06340, United States

5. Medicinal Sciences, ADME CoE, Pfizer Inc., Groton, Connecticut 06340, United States

Funder

Pfizer

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.7b00048

Reference32 articles.

1. Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

2. Drug-Induced Perturbations of the Bile Acid Pool, Cholestasis, and Hepatotoxicity: Mechanistic Considerations beyond the Direct Inhibition of the Bile Salt Export Pump

3. Bile acid profiling in human biological samples: Comparison of extraction procedures and application to normal and cholestatic patients

4. Complementary Functions of the Flippase ATP8B1 and the Floppase ABCB4 in Maintaining Canalicular Membrane Integrity

5. The histidin-loop is essential for transport activity of human MDR3. A novel mutation of MDR3 in a patient with progressive familial intrahepatic cholestasis type 3

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5. Control Compounds for Preclinical Drug-Induced Liver Injury Assessment: Consensus-driven systematic review by the ProEuroDILI Network;2023-11-09

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