P450 3A-Catalyzed O-Dealkylation of Lapatinib Induces Mitochondrial Stress and Activates Nrf2
Author:
Affiliation:
1. Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, Florida 33458, United States
2. Chemistry Department, Faculty of Science, Benha University, Benha 13518, Egypt
Funder
NIH Office of the Director
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.5b00524
Reference34 articles.
1. Liver injury caused by drugs: an update
2. Idiosyncratic Adverse Drug Reactions: Current Concepts
3. Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways
4. Gastrosplenic Fistula From Hodgkin's Lymphoma
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