Unraveling a Combined Inactivation Mechanism of Cytochrome P450s by Genipin, the Major Reactive Aglycone Derived from <i>Gardeniae Fructus</i>-Reference-Cited by-同舟云学术

Unraveling a Combined Inactivation Mechanism of Cytochrome P450s by Genipin, the Major Reactive Aglycone Derived from Gardeniae Fructus

Published:2023-08-25 Issue:9 Volume:36 Page:1483-1494
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Huang Haoyan¹,Zhao Yulin¹,Huang Chunyan¹,Lv Ning¹,Zhao Jie²,Sun Shanliang³,Guo Chaorui¹^ORCID,Zhao Di¹,Chen Xijing¹,Zhang Yongjie¹^ORCID

Affiliation:

1. Clinical Pharmacology Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China

2. Pharmaceutical Animal Experimental Center, China Pharmaceutical University, Nanjing 210009, China

3. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu 210023, China

Funder

Natural Science Foundation of Jiangsu Province

Government of Jiangsu Province

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.3c00102

Reference36 articles.

1. A Review on the Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Geniposide, a Natural Product

2. A review of the ethnopharmacology, phytochemistry, pharmacology and toxicology of Fructus Gardeniae (Zhi-zi)

3. Hepatotoxicity of geniposide in rats

4. Biotransformation of geniposide by human intestinal microflora on cytotoxicity against HepG2 cells

5. Role of intestinal microbiota-mediated genipin dialdehyde intermediate formation in geniposide-induced hepatotoxicity in rats