Delayed Times to Tissue Fixation Result in Unpredictable Global Phosphoproteome Changes

Author:

Gündisch Sibylle12,Grundner-Culemann Kathrin32,Wolff Claudia12,Schott Christina14,Reischauer Bilge14,Machatti Manuela32,Groelz Daniel54,Schaab Christoph36,Tebbe Andreas32,Becker Karl-Friedrich142

Affiliation:

1. Institute of Pathology, Technische Universität München, Trogerstrasse 18, 81675 Munich, Germany

2. Munich Biotech Cluster m4, BioM Biotech Cluster Development GmbH, Am Klopferspitz 19a, 82152 Martinsried, , Germany

3. Evotec (Munich), 82152 Martinsried, Germany

4. The SPIDIA Consortium, , QIAGEN GmbH, QIAGEN Strasse 1, 40724 Hilden, Germany

5. PreAnalytiX GmbH, Feldbachstrasse, CH-8634 Hombrechtikon, Switzerland

6. Max Planck Institute of Biochemistry, 82152 Martinsried, Germany

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

Reference26 articles.

1. A Portrait of Tissue Phosphoprotein Stability in the Clinical Tissue Procurement Process

2. Extreme loss of immunoreactive p-Akt and p-Erk1/2 during routine fixation of primary breast cancer

3. Phosphorylation of tyrosine 1248-ERBB2 measured by chemiluminescence-linked immunoassay is an independent predictor of poor prognosis in primary breast cancer patients

4. Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors

5. Wulfkuhle, J. D.; Berg, D.; Wolff, C.; Langer, R.; Tran, K.; Illi, J.; Espina, V.; Pierobon, M. Deng, J. DeMichele, A.; Walch, A.; Bronger, H.; Becker, I.; Waldhör, C.; Höfler, H.; Esserman, L.(on behalf of the I-SPY 1 TRIAL Investigators: Liotta, L.A; Becker, K.F.; Petricoin, E. F., 3rd)Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mapping.Clin. Cancer Res. 2012, 18 (23) 6426–35

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