Synthesis and Biological Evaluation of Amidine, Guanidine, and Thiourea Derivatives of 2-Amino(6-trifluoromethoxy)benzothiazole as Neuroprotective Agents Potentially Useful in Brain Diseases-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of Amidine, Guanidine, and Thiourea Derivatives of 2-Amino(6-trifluoromethoxy)benzothiazole as Neuroprotective Agents Potentially Useful in Brain Diseases

Published:2009-12-01 Issue:2 Volume:53 Page:734-744
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Anzini Maurizio¹,Chelini Alessia¹,Mancini Alessandra¹,Cappelli Andrea¹,Frosini Maria²,Ricci Lorenzo²,Valoti Massimo²,Magistretti Jacopo³,Castelli Loretta³,Giordani Antonio⁴,Makovec Francesco⁴,Vomero Salvatore¹

Affiliation:

1. Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Università di Siena, Via A. Moro, 53100 Siena, Italy

2. Dipartimento di Neuroscienze, Sezione di Farmacologia, Fisiologia e Tossicologia, Università di Siena, Via A. Moro, 53100 Siena, Italy

3. Dipartimento di Fisiologia, Sezione di Fisiologia Generale, Università di Pavia, Via Forlanini 6, 27100 Pavia, Italy

4. Rottapharm SpA, Via Valosa di Sopra 7, 20052 Monza, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901375r

Reference42 articles.

1. Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

2. Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke