Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

Author:

McCoull William1ORCID,Cheung Tony2,Anderson Erica2,Barton Peter1,Burgess Jonathan1,Byth Kate2,Cao Qing2,Castaldi M. Paola2,Chen Huawei2,Chiarparin Elisabetta1,Carbajo Rodrigo J.1,Code Erin2,Cowan Suzanna1,Davey Paul R.1,Ferguson Andrew D.2ORCID,Fillery Shaun1,Fuller Nathan O.2,Gao Ning2,Hargreaves David1,Howard Martin R.1,Hu Jun2,Kawatkar Aarti2,Kemmitt Paul D.1,Leo Elisabetta1,Molina Daniel M.3,O’Connell Nichole2,Petteruti Philip2,Rasmusson Timothy2,Raubo Piotr1,Rawlins Philip B.1,Ricchiuto Piero1,Robb Graeme R.1,Schenone Monica4,Waring Michael J.1,Zinda Michael2,Fawell Stephen2,Wilson David M.1

Affiliation:

1. Oncology and Discovery Sciences, IMED Biotech Unit, AstraZeneca, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.

2. Oncology and Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gatehouse Park, Waltham, Massachusetts 02451, United States

3. Pelago Bioscience AB, Banvaktsvägen 20, 17148 Solna, Sweden

4. Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, United States

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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