Hybrid Transcription Factor Engineering Activates the Silent Secondary Metabolite Gene Cluster for (+)-Asperlin in Aspergillus nidulans

Author:

Grau Michelle F.1,Entwistle Ruth2,Chiang Yi-Ming13,Ahuja Manmeet2,Oakley C. Elizabeth2,Akashi Tomohiro4,Wang Clay C. C.15ORCID,Todd Richard B.6,Oakley Berl R.2ORCID

Affiliation:

1. Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, United States

2. Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, United States

3. Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan City 71710, Taiwan

4. Division of OMICS Analysis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan

5. Department of Chemistry, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, California 90089, United States

6. Department of Plant Pathology, Kansas State University, 4024 Throckmorton Plant Sciences Center, Manhattan, Kansas 66506, United States

Funder

Hall Family Foundation

U.S. Department of Energy

National Institute of General Medical Sciences

Kansas City Area Life Sciences Institute

Kansas University Endowment Association

Kansas Agricultural Experiment Station

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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