Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action
Author:
Affiliation:
1. Promega Corporation, 2800 Woods Hollow Road, Madison, Wisconsin 53711, United States
2. Promega Biosciences Incorporated, 277 Granada Drive, San Luis Obispo, California 93401, United States
Publisher
American Chemical Society (ACS)
Subject
Molecular Medicine,General Medicine,Biochemistry
Link
http://pubs.acs.org/doi/pdf/10.1021/acschembio.8b00692
Reference50 articles.
1. Prime time for PROTACs
2. Induced protein degradation: an emerging drug discovery paradigm
3. Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?
4. Chemical approaches to targeted protein degradation through modulation of the ubiquitin–proteasome pathway
5. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
Cited by 215 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Structure–Activity Relationship of Potent, Selective, and Orally Bioavailable Molecular Glue Degraders of CK1α;ACS Medicinal Chemistry Letters;2024-09-12
2. Selective Degradation of MLK3 by a Novel CEP1347-VHL-02 PROTAC Compound Limits the Oncogenic Potential of TNBC;Journal of Medicinal Chemistry;2024-08-29
3. Inducing Receptor Degradation as a Novel Approach to Target CC Chemokine Receptor 2 (CCR2);International Journal of Molecular Sciences;2024-08-18
4. Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools for Monitoring Targeted Protein Degradation;ACS Medicinal Chemistry Letters;2024-07-28
5. Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins;Nature Communications;2024-07-10
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3