Electrophile Scanning Reveals Reactivity Hotspots for the Design of Covalent Peptide Binders

Author:

Grob Nathalie M.1,Remarcik Clint2,Rössler Simon L.1ORCID,Wong Jeffrey Y. K.1,Wang John C. K.2,Tao Jason1,Smith Corey L.3,Loas Andrei1ORCID,Buchwald Stephen L.1ORCID,Eaton Dan L.2,López Magdalena Preciado2,Pentelute Bradley L.1456ORCID

Affiliation:

1. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States of America

2. Calico Life Sciences LLC, San Francisco, California 94080, United States of America

3. AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States of America

4. The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, United States of America

5. Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States of America

6. Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States of America

Funder

Massachusetts Life Sciences Center

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Calico Life Sciences

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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