Detection of Active SARS-CoV-2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead-Reference-Cited by-同舟云学术

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Detection of Active SARS-CoV-2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead

Published:2024-04-26 Issue:5 Volume:19 Page:1028-1034
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Yamauchi Yuki¹,Konno Sho¹^ORCID,Omura Noriko¹,Yoshioka Narumi¹,Hingst Alexandra²,Gütschow Michael²^ORCID,Müller Christa E.²^ORCID,Taguchi Akihiro¹,Taniguchi Atsuhiko¹,Kawaguchi Atsushi³,Hayashi Yoshio¹^ORCID

Affiliation:

1. School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan

2. Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn 53121, Germany

3. Institute of Medicine, Transborder Medical Research Center, University of Tsukuba, Tsukuba 305-8575, Japan

Funder

Deutsche Forschungsgemeinschaft

Core Research for Evolutional Science and Technology

Japan Society for the Promotion of Science

Volkswagen Foundation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.4c00024

Reference37 articles.

1. BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

2. SARS-COV-2, infection, transmission, transcription, translation, proteins, and treatment: A review

3. In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs

4. A new coronavirus associated with human respiratory disease in China

5. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

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