Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC-Reference-Cited by-同舟云学术

Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC

Published:2022-06-24 Issue:7 Volume:17 Page:1789-1798
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Swartzel Jake C.¹,Bond Michael J.²,Pintado-Urbanc Andreas P.¹³,Daftary Mehana⁴,Krone Mackenzie W.⁵,Douglas Todd⁵,Carder Evan J.⁵^ORCID,Zimmer Joshua T.³⁴,Maeda Takahiro⁶,Simon Matthew D.³⁴^ORCID,Crews Craig M.¹²⁵^ORCID

Affiliation:

1. Department of Chemistry, Yale University, New Haven, Connecticut 06511, United States

2. Department of Pharmacology, Yale University, New Haven, Connecticut 06511, United States

3. Institute for Biomolecular Design and Discovery, Yale University, West Haven, Connecticut 06516, United States

4. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511, United States

5. Department of Molecular, Cellular, and Developmental Biology, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06511, United States

6. Division of Precision Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan

Funder

National Cancer Institute

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

American Cancer Society

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.2c00145

Reference50 articles.

1. Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS

2. The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases

3. Structural and functional control of the eukaryotic mRNA decapping machinery

4. Mechanistic and Kinetic Analysis of the DcpS Scavenger Decapping Enzyme

5. Insights into the Structure, Mechanism, and Regulation of Scavenger mRNA Decapping Activity

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