An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection

Author:

Wagner Florence F.1,Lundh Morten23,Kaya Taner1,McCarren Patrick2,Zhang Yan-Ling1,Chattopadhyay Shrikanta2,Gale Jennifer P.1,Galbo Thomas4,Fisher Stewart L.5,Meier Bennett C.2,Vetere Amedeo2,Richardson Sarah6,Morgan Noel G.6,Christensen Dan Ploug3,Gilbert Tamara J.2,Hooker Jacob M.17,Leroy Mélanie1,Walpita Deepika2,Mandrup-Poulsen Thomas38,Wagner Bridget K.2,Holson Edward B.1

Affiliation:

1. Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States

2. Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States

3. Department of Biomedical Sciences, University of Copenhagen, Copenhagen 1165, Denmark

4. Department of Internal Medicine, Yale University, New Haven, Connecticut 06520, United States

5. SL Fisher Consulting, LLC, PO Box 3052, Framingham, Massachusetts 01701, United States

6. University of Exeter Medical School, RD&E Hospital, Wonford EX2 5DW, U.K.

7. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Department of Radiology, Harvard Medical School, Charlestown, Massachusetts 02129, United States

8. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 171 77, Sweden

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Stanley Medical Research Institute

Juvenile Diabetes Research Foundation

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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