Overcoming Clopidogrel Resistance: Discovery of Vicagrel as a Highly Potent and Orally Bioavailable Antiplatelet Agent-Reference-Cited by-同舟云学术

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Overcoming Clopidogrel Resistance: Discovery of Vicagrel as a Highly Potent and Orally Bioavailable Antiplatelet Agent

Published:2012-04-02 Issue:7 Volume:55 Page:3342-3352
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shan Jiaqi,Zhang Boyu,Zhu Yaoqiu¹,Jiao Bo²,Zheng Weiyi³,Qi Xiaowei⁴,Gong Yanchun,Yuan Fang⁴,Lv Fusheng⁴,Sun Hongbin

Affiliation:

1. MetabQuest Research and Consulting, 1720 Oak Avenue, Suite 403, Evanston, Illinois 60201, United States

2. Department of Pharmacology, School of Pharmacy, Shandong University, 44 Wenhua West Road, Jinan 250012, China

3. Concord Pharmatech Co., Ltd., 9 Xinglong Road, Nanjing 211800, China

4. Jiangsu Vcare PharmaTech Co., Ltd., 15 Wanshou Road, Nanjing 211800, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300038c

Reference16 articles.

1. Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation

2. Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs

3. Role of Clopidogrel Loading Dose in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Angioplasty

4. Cytochrome P-450 Polymorphisms and Response to Clopidogrel

5. Reduced-Function CYP2C19 Genotype and Risk of Adverse Clinical Outcomes Among Patients Treated With Clopidogrel Predominantly for PCI

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1. The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice;Xenobiotica;2024-08-21

2. Effects of the Thiol Methyltransferase Inhibitor (±)-2,3-Dichloro-α-Methylbenzylamine (DCMB) on the Pharmacokinetics and Metabolism of Vicagrel in Rats;Drug Metabolism and Disposition;2024-07-12

3. Discovery of 2,3-Dihydro[1,4]dioxino[2,3-g]benzofuran Derivatives as Protease Activated Receptor 4 (PAR4) Antagonists with Potent Antiplatelet Aggregation Activity and Low Bleeding Tendency;Journal of Medicinal Chemistry;2024-03-29

4. Vicagrel is hydrolyzed by Raf kinase inhibitor protein in human intestine;Biopharmaceutics & Drug Disposition;2022-12

5. Several non-salt and solid thienopyridine derivatives as oral P2Y12 receptor inhibitors with good stability;Bioorganic & Medicinal Chemistry Letters;2022-11

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