Characterization and Stability Study of Polysorbate 20 in Therapeutic Monoclonal Antibody Formulation by Multidimensional Ultrahigh-Performance Liquid Chromatography–Charged Aerosol Detection–Mass Spectrometry-Reference-Cited by-同舟云学术

Characterization and Stability Study of Polysorbate 20 in Therapeutic Monoclonal Antibody Formulation by Multidimensional Ultrahigh-Performance Liquid Chromatography–Charged Aerosol Detection–Mass Spectrometry

Published:2014-05-02 Issue:10 Volume:86 Page:5150-5157
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Li Yi¹,Hewitt Daniel¹,Lentz Yvonne K.¹,Ji Junyan A.¹,Zhang Taylor Y.¹,Zhang Kelly¹

Affiliation:

1. Small Molecule Pharmaceutical Sciences, ‡Protein Analytical Chemistry, and §Late Stage Pharmaceutical and Process Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States

Funder

Genentech

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ac5009628

Reference29 articles.

1. A thermodynamic analysis of the binding interaction between polysorbate 20 and 80 with human serum albumins and immunoglobulins: A contribution to understand colloidal protein stabilisation

2. Polysorbate 20 prevents the precipitation of a monoclonal antibody during shear

3. Molten Globule Intermediate of Recombinant Human Growth Hormone: Stabilization with Surfactants