1. School of Biomedical and Natural Sciences, Interdisciplinary Biomedical Research Centre, Nottingham Trent University, Nottingham, NG11 8NS, UK, Waters Corporation, Floats Road, Wythenshawe, Manchester, M23 9LZ, UK, AstraZeneca, Alderley Park, Macclesfield, SK10 4TF, Cheshire, UK, and GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK