Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914)-Reference-Cited by-同舟云学术

Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914)

Published:2010-05-14 Issue:11 Volume:53 Page:4379-4389
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ghiron Chiara¹,Haydar Simon N.²,Aschmies Suzan²,Bothmann Hendrick¹,Castaldo Cristiana¹,Cocconcelli Giuseppe¹,Comery Thomas A.²,Di Li²,Dunlop John²,Lock Tim²,Kramer Angela²,Kowal Dianne²,Jow Flora²,Grauer Steve²,Harrison Boyd²,La Rosa Salvatore¹,Maccari Laura¹,Marquis Karen L.²,Micco Iolanda¹,Nencini Arianna¹,Quinn Joanna¹,Robichaud Albert J.²,Roncarati Renza¹,Scali Carla¹,Terstappen Georg C.¹,Turlizzi Elisa¹,Valacchi Michela¹,Varrone Maurizio¹,Zanaletti Riccardo¹,Zanelli Ugo¹

Affiliation:

1. Siena Biotech SpA, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy

2. Chemical Sciences and Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, New Jersey 08543-8000

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901692q

Reference31 articles.

1. Neuronal Nicotinic Acetylcholine Receptors

2. Nicotine and Nicotinic Receptor Involvement in Neuropsychiatric Disorders