Flap Endonuclease 1 Mutations A159V and E160D Cause Genomic Instability by Slowing Reaction on Double-Flap Substrates
Author:
Affiliation:
1. Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Sheffield S3 7HF, U.K.
Funder
Ministry of Higher Education and Scientific Research
Biotechnology and Biological Sciences Research Council
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.8b00891
Reference56 articles.
1. Mechanism of Lagging-Strand DNA Replication in Eukaryotes
2. The Wonders of Flap Endonucleases: Structure, Function, Mechanism and Regulation
3. Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases
4. Flap Endonuclease 1
5. Functional regulation of FEN1 nuclease and its link to cancer
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