Insight into the Therapeutic Selectivity of the Irreversible EGFR Tyrosine Kinase Inhibitor Osimertinib through Enzyme Kinetic Studies-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Insight into the Therapeutic Selectivity of the Irreversible EGFR Tyrosine Kinase Inhibitor Osimertinib through Enzyme Kinetic Studies

Published:2020-03-24 Issue:14 Volume:59 Page:1428-1441
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Zhai Xiang¹^ORCID,Ward Richard A.²^ORCID,Doig Peter¹,Argyrou Argyrides³^ORCID

Affiliation:

1. Mechanistic Biology & Profiling, Discovery Sciences, R&D, AstraZeneca, Waltham, Massachusetts 02451, United States

2. Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.

3. Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.

Funder

AstraZeneca

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.0c00104

Reference46 articles.

1. Cell and Molecular Biology of Epidermal Growth Factor Receptor

2. A Structural Perspective on the Regulation of the Epidermal Growth Factor Receptor

3. Epidermal growth factor receptor (EGFR) signaling in cancer

4. Targeting the EGFR signaling pathway in cancer therapy

5. Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer

Cited by 44 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Demystifying Functional Parameters for Irreversible Enzyme Inhibitors;Journal of Medicinal Chemistry;2024-08-08

2. High-throughput kinetics in drug discovery;SLAS Discovery;2024-07

3. Integrated PBPK-EO modeling of osimertinib to predict plasma concentrations and intracranial EGFR engagement in patients with brain metastases;Scientific Reports;2024-06-03

4. Imidazole[1,5-a]pyridine derivatives as EGFR tyrosine kinase inhibitors unraveled by umbrella sampling and steered molecular dynamics simulations;Scientific Reports;2024-05-28

5. Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations;Journal of Medicinal Chemistry;2024-05-21

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3