Design and Biological Evaluation of the Long-Acting C5-Inhibited <i>Ornithodoros moubata</i> Complement Inhibitor (OmCI) Modified with Fatty Acid-Reference-Cited by-同舟云学术

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Design and Biological Evaluation of the Long-Acting C5-Inhibited Ornithodoros moubata Complement Inhibitor (OmCI) Modified with Fatty Acid

Published:2024-04-09 Issue:5 Volume:35 Page:653-664
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Shangguan Wenwen¹²^ORCID,Li Xiaowan¹²,Wang Yandan²³,Huang Zongqing²⁴,Dong Yuanzhen²⁴,Feng Meiqing¹,Feng Jun²

Affiliation:

1. School of Pharmacy, Fudan University, 201203 Shanghai, China

2. Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 201203 Shanghai, China

3. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, 310014 Hangzhou, China

4. Shanghai Duomirui Biotechnology Co Ltd, 201203 Shanghai, China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.4c00126

Reference43 articles.

1. Clinical promise of next-generation complement therapeutics

2. The complement system: History, pathways, cascade and inhibitors

3. Structure/function of C5 convertases of complement

4. Structural basis of complement membrane attack complex formation

5. Bacterial killing by complement requires membrane attack complex formation via surface‐bound C5 convertases

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