Metabolic Oligosaccharide Engineering with Alkyne Sialic Acids Confers Neuraminidase Resistance and Inhibits Influenza Reproduction

Author:

Heise Torben1,Büll Christian2,Beurskens Daniëlle M.3,Rossing Emiel1,de Jonge Marien I.4,Adema Gosse J.2,Boltje Thomas J.1ORCID,Langereis Jeroen D.4

Affiliation:

1. Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands

2. Department of Radiation Oncology, Radiotherapy & OncoImmunology Laboratory, Radboudumc, Geert Grooteplein Zuid 32, 6525 GA Nijmegen, The Netherlands

3. Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands

4. Laboratory of Pediatric Infectious Diseases, Radboud Center for Infectious Diseases, Radboudumc, Geert Grooteplein Zuid 32, 6525 GA Nijmegen, The Netherlands

Funder

KWF Kankerbestrijding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Netherlands Research School of Chemical Biology, Leiden University

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

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