Site-Specific Conjugation of Native Antibody: Transglutaminase-Mediated Modification of a Conserved Glutamine While Maintaining the Primary Sequence and Core Fc Glycan via Trimming with an Endoglycosidase-Reference-Cited by-同舟云学术

Site-Specific Conjugation of Native Antibody: Transglutaminase-Mediated Modification of a Conserved Glutamine While Maintaining the Primary Sequence and Core Fc Glycan via Trimming with an Endoglycosidase

Published:2024-03-18 Issue:4 Volume:35 Page:465-471
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Sadiki Amissi¹^ORCID,Liu Shanshan¹^ORCID,Vaidya Shefali R.¹,Kercher Eric M.²,Lang Ryan T.²,McIsaac James¹^ORCID,Spring Bryan Q.²,Auclair Jared R.¹^ORCID,Zhou Zhaohui Sunny¹

Affiliation:

1. Department of Chemistry and Chemical Biology, Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, Massachusetts 02115, United States

2. Translational Biophotonics Cluster, Department of Physics, Department of Bioengineering, Northeastern University, Boston, Massachusetts 02115, United States

Funder

Northeastern University

National Institute of General Medical Sciences

National Science Foundation

John Hatsopoulos Scholar Award

Amgen Wolfgang Goetzinger Scholar Awards in Life Science Analysis

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.4c00013

Reference66 articles.

1. Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

2. Strategies and challenges for the next generation of antibody–drug conjugates

3. Site-specific conjugation of native antibody

4. Contemporary approaches to site-selective protein modification

5. Structural Characterization of a Monoclonal Antibody–Maytansinoid Immunoconjugate

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