Modular Synthesis and in Vitro and in Vivo Antimalarial Assessment of C-10 Pyrrole Mannich Base Derivatives of Artemisinin-Reference-Cited by-同舟云学术

Modular Synthesis and in Vitro and in Vivo Antimalarial Assessment of C-10 Pyrrole Mannich Base Derivatives of Artemisinin

Published:2009-12-03 Issue:2 Volume:53 Page:633-640
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pacorel Bénédicte¹,Leung Suet C.¹,Stachulski Andrew V.¹,Davies Jill²,Vivas Livia³,Lander Hollie³,Ward Stephen A.²,Kaiser Marcel³,Brun Reto³,O’Neill Paul M.¹⁴

Affiliation:

1. Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.

2. Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, U.K.

3. Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K.

4. MRC Centre for Drug Safety Science, Department of Pharmacology, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3GE, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901216v

Reference37 articles.

1. Preventive effect of artemether in experimental animals infected with Schistosoma mansoni

2. Antimalarial activity of new water-soluble dihydroartemisinin derivatives. 2. Stereospecificity of the ether side chain

3. C-10 Ester and Ether Derivatives of Dihydroartemisinin − 10-α Artesunate, Preparation of Authentic 10-β Artesunate, and of Other Ester and Ether Derivatives Bearing Potential Aromatic Intercalating Groups at C-10

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