exo-2-(Pyridazin-4-yl)-7-azabicyclo[2.2.1]heptanes: Syntheses and Nicotinic Acetylcholine Receptor Agonist Activity of Potent Pyridazine Analogues of (±)-Epibatidine-Reference-Cited by-同舟云学术

exo-2-(Pyridazin-4-yl)-7-azabicyclo[2.2.1]heptanes: Syntheses and Nicotinic Acetylcholine Receptor Agonist Activity of Potent Pyridazine Analogues of (±)-Epibatidine

Published:2000-11-30 Issue:1 Volume:44 Page:47-57
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Che Daqing¹,Wegge Thomas¹,Stubbs Milton T.¹,Seitz Gunther¹,Meier Heinrich¹,Methfessel Christoph¹

Affiliation:

1. Institut für Pharmazeutische Chemie, Universität Marburg, Marbacher Weg 6, D-35032 Marburg/Lahn, Germany, Bayer AG, PH-R-CR MC IV, Geschäftsbereich Pharma, Chemische Forschung, Medizinische Chemie IV, D-42096 Wuppertal, Germany, and Bayer AG, Central Research Biophysics Department, D-51368 Leverkusen, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000949w

Reference49 articles.

1. Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an Ecuadoran poison frog

2. Total Synthesis and Determination of the Absolute Configuration of Epibatidine

3. Epibatidine: Pharmacological Properties of a Novel Nicotinic Acetylcholine Receptor Agonist and Analgesic Agent

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