Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants

Author:

Hegron Alan123,Huh Eunna4,Deupi Xavier56ORCID,Sokrat Badr23,Gao Wenwen1,Le Gouill Christian3,Canouil Mickaël78,Boissel Mathilde78,Charpentier Guillaume9,Roussel Ronan101112,Balkau Beverley1314,Froguel Philippe7815,Plouffe Bianca23ORCID,Bonnefond Amélie7815,Lichtarge Olivier416,Jockers Ralf1ORCID,Bouvier Michel23ORCID

Affiliation:

1. Université de Paris, Institut Cochin, CNRS, INSERM, F-75014 Paris, France

2. Department of Biochemistry and Molecular Medicine, University de Montréal, Montreal, Quebec, H3T 1J4 Canada

3. Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, H3T 1J4 Canada

4. Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas 77030, United States of America

5. Laboratory of Biomolecular Research, Paul Scherrer Institute (PSI), 5232 Villigen, Switzerland

6. Condensed Matter Theory group, Paul Scherrer Institute (PSI), 5232 Villigen, Switzerland

7. Inserm UMR1283, CNRS UMR8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille, 59000, France

8. University of Lille, Lille University Hospital, Lille, 59000, France

9. Centre d’Étude et de Recherche pour l’Intensification du Traitement du Diabète, 91000, Evry, France

10. Department of Diabetology Endocrinology Nutrition, Hôpital Bichat, DHU FIRE, Assistance Publique Hôpitaux de Paris, 75004 Paris, France

11. Inserm U1138, Centre de Recherche des Cordeliers, 75006 Paris, France

12. UFR de Médecine, University Paris Diderot, Sorbonne Paris Cité, 75006 Paris, France

13. Inserm U1018, Center for Research in Epidemiology and Population Health, 94805 Villejuif, France

14. University Paris-Saclay, University Paris-Sud, 94270 Villejuif, France

15. Department of Metabolism, Imperial College London, London, W12 0NN, United Kingdom

16. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, United States

Funder

Canadian Institutes of Health Research

Fonds de Recherche du Qu??bec - Sant??

Agence Nationale de la Recherche

Institut National de la Sant?? et de la Recherche M??dicale

Diabetes UK

Diabetes Canada

Canada Research Chairs

Wellcome Trust

Centre National de la Recherche Scientifique

Universit?? de Montr??al

China Scholarship Council

National Institutes of Health

Fondation de la Recherche M??dicale

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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