Identification of Novel UGT1A1 Variants Including UGT1A1 454C>A through the Genotyping of Healthy Participants of the HPTN 077 Study

Author:

Seneviratne Herana Kamal1ORCID,Hamlin Allyson N.1,Li Sue2,Grinsztejn Beatriz3,Dawood Halima4,Liu Albert Y.5,Kuo Irene6,Hosseinipour Mina C.7,Panchia Ravindre8,Cottle Leslie2,Chau Gordon2,Adeyeye Adeola9,Rinehart Alex R.10,McCauley Marybeth11,Eron Joseph S.12,Cohen Myron S.12,Landovitz Raphael J.13,Hendrix Craig W.1,Bumpus Namandjé N.14

Affiliation:

1. Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States

2. Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, United States

3. Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil

4. Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban 4041, South Africa

5. Bridge HIV, Population Health Division, San Francisco Department of Health, San Francisco, California 94102, United States

6. Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, George Washington University, Washington, District of Columbia 20052, United States

7. UNC Project-Malawi, Lilongwe, Malawi

8. Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital, Soweto 1864, South Africa

9. Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, United States

10. ViiV Healthcare, Durham, North Carolina 27709, United States

11. FHI360, Durham, North Carolina 27701, United States

12. University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

13. UCLA Center for Clinical AIDS Research and Education, Los Angeles, California 90035, United States

14. Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States

Funder

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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