Diastereomers of Coibamide A Show Altered Sec61 Client Selectivity and Ligand-Dependent Activity against Patient-Derived Glioma Stem-like Cells-Reference-Cited by-同舟云学术

Diastereomers of Coibamide A Show Altered Sec61 Client Selectivity and Ligand-Dependent Activity against Patient-Derived Glioma Stem-like Cells

Published:2024-05-14 Issue:6 Volume:7 Page:1823-1838
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Mattos Daphne R.¹,Neves Willian das²,Kitamura Takashi³,Pradhan Richa²,Wan Xuemei¹,da Hora Cintia Carla²,Tranter Dale⁴^ORCID,Kazemi Soheila¹,Yu Xinhui¹,Tripathy Nirmalya¹^ORCID,Paavilainen Ville O.⁴^ORCID,McPhail Kerry L.¹^ORCID,Oishi Shinya³⁵^ORCID,Badr Christian E.²^ORCID,Ishmael Jane E.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, United States

2. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States

3. Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan

4. Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland

5. Laboratory of Medicinal Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan

Funder

National Institute of Neurological Disorders and Stroke

Sigrid Juséliuksen Säätiö

Takeda Science Foundation

Research Council of Finland

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.4c00049

Reference80 articles.

1. Coibamide A, a Potent Antiproliferative Cyclic Depsipeptide from the Panamanian Marine Cyanobacterium Leptolyngbya sp.

2. Natural products as modulators of eukaryotic protein secretion

3. Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins

4. Mechanisms of Sec61/SecY-Mediated Protein Translocation Across Membranes

5. Structure of the Sec61 channel opened by a signal sequence