Discovery of an Opioid κ Receptor Selective Pure Antagonist from a Library of N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)morphans-Reference-Cited by-同舟云学术

Discovery of an Opioid κ Receptor Selective Pure Antagonist from a Library of N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)morphans

Published:2002-07-04 Issue:16 Volume:45 Page:3524-3530
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thomas James B.¹,Atkinson Robert N.¹,Namdev Nivedita¹,Rothman Richard B.¹,Gigstad Kenneth M.¹,Fix Scott E.¹,Mascarella S. Wayne¹,Burgess Jason P.¹,Vinson N. Ariane¹,Xu Heng¹,Dersch Christina M.¹,Cantrell Buddy E.¹,Zimmerman Dennis M.¹,Carroll F. Ivy¹

Affiliation:

1. Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, North Carolina 27709, Clinical Psychopharmacology Section, NIDA Addiction Research Section, P.O. Box 5180, Building C, 4980 Eastern Avenue, Baltimore, Maryland 21224, and Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 4628

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm020084h

Reference19 articles.

1. Selective opioid receptor agonists and antagonists: research tools and potential therapeutic agents

2. Deuterium isotope effects in the in vivo metabolism of cotinine

3. Racemic and optically active 2,9-dimethyl-5-(m-hydroxyphenyl)morphans and pharmacological comparison with the 9-demethyl homologs

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