Design and Synthesis of Thiazole Scaffold-Based Small Molecules as Anticancer Agents Targeting the Human Lactate Dehydrogenase A Enzyme-Reference-Cited by-同舟云学术

Design and Synthesis of Thiazole Scaffold-Based Small Molecules as Anticancer Agents Targeting the Human Lactate Dehydrogenase A Enzyme

Published:2023-05-10 Issue:20 Volume:8 Page:17552-17562
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Sharma Dolly¹²,Singh Mamta²,Joshi Jayadev³,Garg Manoj²,Chaudhary Vidhi⁴,Blankenberg Daniel³,Chandna Sudhir⁵,Kumar Vinit²,Rani Reshma⁶^ORCID

Affiliation:

1. Amity Institute of Biotechnology, Amity University, Noida 201303, Uttar Pradesh, India

2. Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Noida 201303, Uttar Pradesh, India

3. Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States

4. India Institute of Technology Patna, Patna 801106, India

5. Institute of Nuclear Medicine & Allied Science, Defense Research Development Organization, Delhi 110054, India

6. Drug Discovery, Jubilant Biosys, Knowledge Park-2, Greater Noida 201306, India

Funder

Science and Engineering Research Board

Amity University

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c07569

Reference33 articles.

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3. Kumar, V.; Rani, R. Lactate dehydrogenase enzyme: An old enzyme but new viable target offers new hope in cancer therapeutics. Lactate Dehydrogenase (LDH): Biochemistry, Function and Clinical Significance 1.

4. Role of LDH in tumor glycolysis: Regulation of LDHA by small molecules for cancer therapeutics

5. Intervention on lactate in cancer: A promising approach for the development of cancer therapeutics

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