Synthesis and Structure of Novel Phenothiazine Derivatives, and Compound Prioritization via In Silico Target Search and Screening for Cytotoxic and Cholinesterase Modulatory Activities in Liver Cancer Cells and In Vivo in Zebrafish-Reference-Cited by-同舟云学术

Synthesis and Structure of Novel Phenothiazine Derivatives, and Compound Prioritization via In Silico Target Search and Screening for Cytotoxic and Cholinesterase Modulatory Activities in Liver Cancer Cells and In Vivo in Zebrafish

Published:2024-07-03 Issue:28 Volume:9 Page:30594-30614
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Kisla Mehmet Murat¹²^ORCID,Yaman Murat³^ORCID,Zengin-Karadayi Fikriye¹,Korkmaz Busra⁴,Bayazeid Omer⁴^ORCID,Kumar Amrish⁵,Peravali Ravindra⁵,Gunes Damla³,Tiryaki Rafed Said⁴,Gelinci Emine⁶,Cakan-Akdogan Gulcin⁶⁷^ORCID,Ates-Alagoz Zeynep¹,Konu Ozlen³⁴⁸^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Ankara, Turkey

2. Graduate School of Health Sciences, Ankara University, 06100 Ankara, Turkey

3. Interdisciplinary Program in Neuroscience, Bilkent University, 06800 Ankara, Turkey

4. Department of Molecular Biology and Genetics, Bilkent University, 06800 Ankara, Turkey

5. Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany

6. Izmir Biomedicine and Genome Center (IBG), 35340 Izmir, Turkey

7. Medical Biology Department, Dokuz Eylul University, 35340 Izmir, Turkey

8. UNAM-Institute of Materials Science and Nanotechnology, Bilkent University, 06800 Ankara, Turkey

Funder

European Cooperation in Science and Technology

T?rkiye Bilimsel ve Teknolojik Arastirma Kurumu

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c06532

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1. Potential antitumor agents XVIII (1). Synthesis and cytotoxic activity of phenothiazine derivatives

2. SYNTHESIS AND SPECTRAL STUDIES OF NITROSOUREA DERIVATIVES OF 6-BROMO AND 6-CHLORO-2,3-DIHYDRO-1,4-BENZOTHIAZINES AS POSSIBLE ANTICANCER AGENTS

3. Repurposing Antidepressants and Phenothiazine Antipsychotics as Efflux Pump Inhibitors in Cancer and Infectious Diseases

4. Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells